Text written in Basque and translated automatically by Elia without any subsequent editing. SEE ORIGINAL

What is Alzheimer's?

As you get older, Alzheimer's can strike anyone. It doesn’t matter about race, socio-economic level or sex. What is Alzheimer's?

As you get older, Alzheimer's can strike anyone. It does not matter about race, socio-economic level or sex. It is a condition that is directly related to old age. In general, it is tolerated by people over the age of 60-65. There is, however, a particular variant of Alzheimer's that is tolerated by younger people. This variant is scarce, but more serious, because the disease spreads more quickly. This is absolutely genetic Alzheimer's. In all other cases, it is not so clear what causes the disease.

It is a very complex disease that, curiously, the Teknopolis team wanted to know in depth. For this reason, we have prepared a monographic session dedicated to Alzheimer’s. Let’s start by looking at what Alzheimer’s is.

ENRIQUE ARRIOLA; Geriatra. The Matia Foundation: It is a disease that has been proven to affect older people.
Basically, it's a disease that older people suffer from.

JAVIER YANGUAS; Director of R&D. ABOUT INGEMA: We can't turn old age around.

[BEGOÑA INDAKOETXEA; Neurologist]. San Sebastian Hospital: Everyone forgets things in their daily lives, but that's not what it is. It's forgetting more and more and more fundamental things. Alzheimer’s disease: the name

itself causes panic; in fact, it is associated with the degeneration of both the body and the mind. In addition, not only the patient but also the family members have to suffer the impact of the disease. first described in 1906 by Emil Kraepelin and Alois Alzheimer in their respective fields, it is a neurodegenerative disease that is chronic and progressive.

ENRIQUE ARRIOLA; Geriatra. The Matia Foundation: We may say that it is an edad-dependent disease. It's a matter of deciding, a major age, more people than you can handle the disease.
It is an age-related disease, that is, the older you get, the more people will suffer from the disease.

[BEGOÑA INDAKOETXEA; Neurologist]. San Sebastian Hospital: From the age of sixty-five, the incidence doubles every five years. I mean, the longer we live, the more dangerous. Women and men are sick, there is no difference, but in the Alzheimer's Disease lists women are always more, probably because there are more women in old age.

Brain aging and dementias are closely related, and Alzheimer’s is currently the major causative agent of dementia. Therefore, as society ages, the prevalence of Alzheimer’s will inevitably increase. But not everyone will be affected in the same way, the one with an active mind will be less at risk.

JAVIER YANGUAS; Director of R&D. ABOUT INGEMA: In general, if you take all the people in the world with Alzheimer’s, it is clear that those who have cultivated the brain have fewer options. This is clear epidemiologically. The thing is, even if you have two careers, that doesn't mean you won't get Alzheimer's in your case.
We use a variable for research that is important to understand it, it is called work complexity, work completeness, or I don’t know how to say it. What is work complexity? Learn, but not only learn, if you usually use your brain in life to do your work and your life: read, make decisions, make projects, learn for your work, that you have to do different tasks... if you move it and achieve this complexity, it is clear that you have few options, because there is evidence. When and how the symptoms appear depends on the lifestyle of each person, what the

environment requires.

In a study with some Canadian legumes, it was observed that the brains of some of them had lesions caused by Alzheimer's disease, but in their daily life they did not show symptoms, probably because they lived in an environment with low levels of demand.

Anyway, the disease is already in the brain for the onset of symptoms. The degeneration of the brain usually begins eight to ten years before the first symptoms appear. But an active brain has a cognitive reserve, in the language of experts, that is, it has a greater ease of adaptation to everyday events, despite having Alzheimer’s.

ENRIQUE ARRIOLA; Geriatra. The Matia Foundation: The problems arising at the cerebral level are caused by proteins which are found to be involved in vasculature neurons which are amyloid plaques and neurofibrillary tangles, which are caused primarily by the destruction of the neuron and alteration of the neuron which is the cerebral level. The problems that arise in the brain are caused by a series of proteins that accumulate in neurons, amyloid plaques and neurofibrillary tangles; they destroy neurons and disrupt all brain circuits. [BEGOÑA INDAKOETXEA; Neurologist].

San Sebastian Hospital: Alzheimer's usually begins in the temporal lobe. In the center, for example, at the entrance door of memory or memory. There is a place that we call the hippocampus, from which new things enter our brain to settle in it. So, how does it start? In general, with a lack of memory: new things cannot be learned and are forgotten. It

affects not only the immediate memory, but also the episodic one, that is, the patient begins to forget the special events that occurred during his life. Usually, no special importance is given to forgetting the key or leaving the fires on; age is the excuse.

But if someone can’t remember when their grandchild was born, or if they ask the same thing over and over again, he may not notice anything, but those around him are alarmed. These may be the first clear symptoms of Alzheimer’s.

In any case, it is surprising: despite the loss of memory, patients remember very clearly the old issues: the house where they were born, their parents, childhood issues... Remote memory is barely affected by Alzheimer’s.

Alzheimer’s does not just affect memory.

JAVIER YANGUAS; Director of R&D. ABOUT INGEMA: When the disease develops slowly, it affects both attention, language, and mammary, praxis, behavior, and behaviors. And as time goes on, people slowly lose these functions and dependency arises. Some patients get lost

in the street, they don’t know how to get home because they don’t know where they are. In general, they lose their skills. In addition, there are also symptoms that affect affectivity and character. It is common for depression to occur at some stage of the disease, or behavioral disorders.

The symptoms and development of the disease vary widely from patient to patient. So much so that it makes you think that Alzheimer's is more than just a disease. Experts have a lot of work to do to determine the cause of Alzheimer’s disease.

[BEGOÑA INDAKOETXEA; Neurologist]. San Sebastian Hospital: The biggest risk factor is genetic. It is usually not a gene, but many genes increase the risk. Then, outside of this, it is observed that vascular risk factors are increasingly also related to Alzheimer's disease. That is, it is observed that things that are bad for the heart, or risk factors for mental infarctions or vascular diseases, are also bad for Alzheimer's. Alzheimer’s disease has

been on the lips of doctors for more than a hundred years. Great progress has been made, but there is still research to be done.