They have significantly improved a gene editing technique
They have significantly improved a gene editing technique
The gene editing system called prime editing has been significantly improved by some MIT researchers. They have greatly reduced the probability of introducing errors in the edition. This could allow the development of safer and more reliable treatments for various genetic diseases.
The Prime edition was presented in 2019: A CRISPR-based system that was more accurate and had fewer unintended effects than it was. The use of this technique is becoming increasingly widespread, but it still generates more errors than desired, sometimes by introducing new DNA fragments where they are not needed. These defects usually have no effect, but in some cases they can cause tumors or other problems.
MIT researchers have now found a way to lower the error rate by using modified versions of some of the proteins involved in the process. In particular, some mutations in the Cas9 protein were found to result in fewer errors. Well, the combination of some Cas9 protein variants has succeeded in significantly reducing the error rate from a seven edition error to a 101 edition error in the most commonly used editing mode, or from a 122 edition error to a 543 edition error when the high precision mode is used. The results are published in the journal Nature.
The new editor has been called vPE. Now, researchers want to improve efficiency, and they’re also investigating ways to bring publishers to specific body tissues, an age-old challenge in gene therapy.
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