"Medicine is very interesting, but I needed something more"

The doctor Aaron Ciechanover participated in the congress Passion for Knowledge, held in San Sebastian. In 2004 he received the Nobel Prize in Chemistry for his research to understand the degradation of proteins and in the congress a conference was given on whether man can cure all diseases someday.

"Medicine is very interesting, but I needed something more"


Aaron Ciechanover: "Medicine is very interesting, but I needed something more"
01/11/2010 | Roa Zubia, Guillermo | Elhuyar Zientzia Komunikazioa
Your work is between chemistry and physiology. In fact, he received the Nobel Prize for research into the degradation of proteins and ubiquitine. At that time, protein synthesis was very much studied, but not the opposite process.

Yes, it is true. People were especially interested in protein synthesis, genetics: how DNA produces the proteins needed to form this admirable body. And for many years it has been considered that the degradation and destruction of proteins is not important. Something similar happens when we eat a chuleta or a seafood or whatever. We put it to the stomach and it disappears. People had no importance at all.

We, however, thought that yes, because we had suspicions of that importance. And in the end it has been seen that it is a very important issue. Mainly for quality control. Proteins are very complex structures that are affected by temperature, oxygen, chemicals and pollution, they stop working and fold badly, so we must discard them. We cannot stack them in the body.

It is like garbage; if you accumulate the garbage of Donostia, you will put upside down the city. No matter what a day, no matter what two days, but if three, four or five days occur, garbage will accumulate, the smell of the city will spread, diseases will spread, cats and dogs will come and it will be a disaster. In the body it is the same. If bad proteins accumulate, they will cause many diseases and therefore we must constantly destroy them.

And for this purpose the body marks the proteins. Can a rapid protein destruction mechanism be considered?

Yes, that's it. You have to mark the proteins so that the system can differentiate between good and bad proteins. Comparable with the example of garbage. You put the garbage in plastic bags and the dumpsters know they have to throw it. But they will not throw in the trash, for example, a car that is next to them. Thanks to the brand, the collectors know what the trash is and what not.

And with proteins the same happens. The body puts a "red" mark called ubiquitine (a protein too). And the system knows that it must destroy all the proteins that have ubiquitine in the back. That is the main idea. It is a selection system. In life we have to be very specific. We cannot destroy everything or build everything. We need to be specific. And in this case we should lead to protein reduction.

It is a work done with proteins and at the same time chemical. It is a work between two areas.
(Photo: Alex Iturralde/DIPC)

And I am a doctor. I am a doctor.

But in the autobiography he wrote for the Nobel Foundation he says at one point he decided that he did not want to be a "practical doctor". Why?

Convinced, moreover. Medicine is very interesting and has great challenges, but I needed something more: I needed to understand the mechanisms of diseases. Doctors treat diseases, but my interest is to know how they occur. It is a personal interest, it is not something better than the other, it is the result of my curiosity.

Sometimes we think that there are many fields not awarded in science. Is it very important?

There are several answers to this question. The first is that the Nobel Prize was created at the will of Alfred Nobel. This is the money of a person who acquired it from the sale of the dynamite and who wanted to reward the great achievements. And decided to reward the achievements in: Physics, Chemistry, Medicine, Peace and Literature. Then came the prize of Economy, but it was not his decision. In fact, Economics is not a Nobel prize, although it is mixed with others (the full name is that of the Bank of Sweden in tribute to Alfred Nobel). You can't decide what the community of Novels must award because it is a decision to Alfred Nobel's letter.

This is a part of the answer. The other part is that prizes are not a goal of life. I mean people work to make discoveries, to advance; you don't work to win a prize. When I was born and started studying, and I started working, I had no awards in mind. Sure, then the prizes came to me, but they were not a goal in my life. The awards are a social recognition to our discoveries. And there are awards for the recognition of areas in which no other awards are awarded. There are journalistic awards like the Pulitzer Prize, there are architectural awards like the Pritzker Prize, computer science awards like the Turing Prize, mathematics awards like the Fields medals, etc. People know how to recognize good work. I think that is the answer: what is achieved in other areas is also recognized. But we don't work to win prizes, we work to improve human life. The prizes are a secondary issue.

However, the Nobel Prize provokes changes in the award-winning field...
Aaron Ciechanover at a conference event Passion for Knowledge with the director of DIPC, Pedro Miguel Etxenike. Ed. : Alex Iturralde/DIPC.

Yes, no doubt, yes. The Nobel Prizes teach the public physics, chemistry or medicine.

In your case also detected the change?

Yes, of course. But once again we must understand that society creates awards in recognition of a discovery. And that what is important is the same discovery and not recognition.

So, does the value of the Nobel prize relativize?

It is a game. A statement. It is very good to pick up the prize, it is very well the recognition, but in many other areas there is no place. They may have to give two or three Nobel Prizes a year and thus be able to award many fields. The Nobel Prizes do not reach all areas and there are many areas left without awarding, and yet they are important areas.

Degradation of proteins
The doctor Aaron Ciechanover and his colleagues discovered the importance of protein degradation. Proteins are the molecular workers of the body, and as important as having the opportunity to perform this work, it is the possibility to interrupt it quickly.
To do this, the body sticks another protein, the famous ubiquitine, to a protein that works. Fernando Cossio, a UPV chemist, said at a conference that ubiquitine is similar to the kiss of Judas. It marks the fate of the protein, puts it in the process of destruction. For his discovery, Ciechanover received the 2004 Nobel Prize in Chemistry.
Jewish Ethic
Aaron Ciechanover was born in Haifa, Israel. His family was originally from Poland, but the Second World War led him to flee to Palestine (then a British protectorate), where Aaron was born in 1947. Ciechanover is a Jew of culture who reflects, among other things, in the scientific field. Ciechanover periodically carries out an ethical reflection on science, for which he meets with other doctors and scientists in the school of rabbis to analyze how the Jewish laws are combined with the ethics of science.
Puente Roa, Guillermo
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